Cerebral Cortex doi:10.1093/cercor/bhr025 Relationships between Beta-Amyloid and Functional Connectivity in Different Components of the Default Mode Network in Aging
نویسندگان
چکیده
Elizabeth C. Mormino, Andre Smiljic, Amynta O. Hayenga, Susan H. Onami, Michael D. Greicius, Gil D. Rabinovici, Mustafa Janabi, Suzanne L. Baker, Irene V. Yen, Cindee M. Madison, Bruce L. Miller and William J. Jagust Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304 USA, Division of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 USA, Memory and Aging Center, University of California San Francisco, San Francisco, CA 94117, USA and Department of Neurology, University of California San Francisco, San Francisco, CA 94117 USA
منابع مشابه
Effects of Beta-Amyloid on Resting State Functional Connectivity Within and Between Networks Reflect Known Patterns of Regional Vulnerability.
Beta-amyloid (Aβ) deposition is one of the hallmarks of Alzheimer's disease (AD). However, it is also present in some cognitively normal elderly adults and may represent a preclinical disease state. While AD patients exhibit disrupted functional connectivity (FC) both within and between resting-state networks, studies of preclinical cases have focused primarily on the default mode network (DMN)...
متن کاملA comprehensive study of whole-brain functional connectivity in children and young adults.
Over the past decade, examination of functional connectivity using functional magnetic resonance imaging has become an important tool to investigate functional changes in patient populations, healthy aging, and recently also child development. Most prior developmental studies focused on functional connectivity between brain regions important for cognitive or emotional control and the so-called ...
متن کاملResting-state functional connectivity reflects structural connectivity in the default mode network.
Resting-state functional connectivity magnetic resonance imaging (fcMRI) studies constitute a growing proportion of functional brain imaging publications. This approach detects temporal correlations in spontaneous blood oxygen level-dependent (BOLD) signal oscillations while subjects rest quietly in the scanner. Although distinct resting-state networks related to vision, language, executive pro...
متن کاملImpaired long distance functional connectivity and weighted network architecture in Alzheimer's disease.
Alzheimer's disease (AD) is increasingly recognized as a disconnection syndrome, which leads to cognitive impairment due to the disruption of functional activity across large networks or systems of interconnected brain regions. We explored abnormal functional magnetic resonance imaging (fMRI) resting-state dynamics, functional connectivity, and weighted functional networks, in a sample of patie...
متن کاملRegional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects.
Although previous studies demonstrated decreased functional connectivity in the default mode network in the cognitively normal older adults with amyloid burden, effects of amyloid burden in the other large-scale intrinsic connectivity networks are not yet clear. The aim of this study was to investigate the distinctive association pattern of amyloid-β deposition on the three large-scale intrinsi...
متن کامل